Racial/ethnic disparities in basal muscle protein metabolism

Is Cancer Cachexia Attributed to Impairments in Basal or Postprandial Muscle Protein Metabolism?

Cachexia is a significant clinical problem associated with very poor quality of life, reduced treatment tolerance and outcomes, and a high mortality rate. Mechanistically, any sizeable loss of skeletal muscle mass must be underpinned by a structural imbalance between muscle protein synthesis and breakdown rates. Recent data indicate that the loss of muscle mass with aging is, at least partly, a...

Whole body and forearm substrate metabolism in hyperthyroidism: evidence of increased basal muscle protein breakdown.

Thyroid hormones have significant metabolic effects, and muscle wasting and weakness are prominent clinical features of chronic hyperthyroidism. To assess the underlying mechanisms, we examined seven hyperthyroid women with Graves' disease before (Ht) and after (Eut) medical treatment and seven control subjects (Ctr). All subjects underwent a 3-h study in the postabsorptive state. After regiona...

Muscle protein metabolism during sepsis

Introduction One of the most pronounced metabolic changes after injury, sepsis and other critical illness is increased urinary excretion of nitrogen, resulting in negative nitrogen balance. There is evidence that skeletal muscle is the major source of nitrogen in these conditions. Muscle catabolism during sepsis is mainly caused by increased protein degradation, in particular myofibrillar prote...

Genetic Strain-dependent Protein Metabolism and Muscle

Regulation of Protein Metabolism in Exercise and Recovery Aging, exercise, and muscle protein metabolism

Koopman R, van Loon LJ. Aging, exercise, and muscle protein metabolism. J Appl Physiol 106: 2040–2048, 2009. First published January 8, 2009; doi:10.1152/japplphysiol.91551.2008.—Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic disease. The age-related loss of skeleta...